SCHEMBL21163172

SCHEMBL21163172

C1CCCCC(c2nnc([C@@H]3CCCN3)o2)CCCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.45
CYP1A2 P05177 2/20 0.45
CYP2C9 P11712 2/20 0.45
LMNA P02545 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 5/20 0.41
ALOX15B O15296 1/20 0.41
MEN1 O00255 1/20 0.40
HPGD P15428 1/20 0.40
MAPT P10636 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
POLB P06746 1/20 0.40
CHRM2 P08172 3/20 0.38
CHRM4 P08173 2/20 0.38
CHRM5 P08912 2/20 0.38
CHRM1 P11229 2/20 0.38
CHRM3 P20309 2/20 0.38
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24623064 0.80 CYP2C19 (0.55) CYP2C19LMNAKMT2AALDH1A1ALOX15B
SCHEMBL14305108 0.78 CYP2C19 (0.53) CYP2C19LMNAKMT2AALDH1A1ALOX15B
SCHEMBL22602165 0.77 CYP2C19 (0.36) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL16399969 0.76 CYP1A2 (0.50) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL16399967 0.76 CYP1A2 (0.50) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL19914300 0.76 CYP1A2 (0.46) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL16399731 0.75 CYP1A2 (0.46) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL16399734 0.75 CYP1A2 (0.46) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL22966580 0.72 CYP1A2 (0.44) CYP2C19CYP1A2CYP2C9LMNACYP3A4
SCHEMBL21163832 0.71 CYP1A2 (0.41) CYP2C19CYP1A2CYP2C9CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2906553-B1 OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES IDORSIA PHARMACEUTICALS LTD (CH) 2019-06-26 EP disclosed