Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29639826 | 0.86 | HTR1D (0.49) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL6688375 | 0.82 | KDM4E (0.69) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5098532 | 0.82 | CYP1A2 (0.59) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL22510037 | 0.80 | KDM4E (0.52) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7808036 | 0.80 | MAPT (0.64) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5104848 | 0.80 | GFER (0.56) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7805753 | 0.79 | MAPT (0.62) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5098076 | 0.79 | MAPT (0.62) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL15714761 | 0.78 | KDM4E (0.68) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL22510035 | 0.76 | MAPT (0.53) | MAPTMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508477-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |