Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591086 | 0.87 | NPC1 (0.47) | NPC1KDRSYKHDAC3 | |
| SCHEMBL21167549 | 0.86 | NPC1 (0.42) | NPC1KDRTGFBR1SYKHDAC3 | |
| SCHEMBL22476000 | 0.85 | GRM5 (0.41) | GRM5NPC1KDRRAB9AL3MBTL1 | |
| SCHEMBL21167661 | 0.85 | NPC1 (0.45) | NPC1KDRSYKHDAC3 | |
| SCHEMBL21167596 | 0.84 | MAPT (0.43) | NPC1KDRRAB9ASYKHDAC3 | |
| SCHEMBL21167658 | 0.83 | NPC1 (0.45) | NPC1KDRSYKHDAC3 | |
| SCHEMBL21167590 | 0.82 | SYK (0.43) | NPC1KDRRAB9AL3MBTL1TGFBR1 | |
| SCHEMBL21167711 | 0.82 | KDR (0.42) | NPC1KDRRAB9ASYKHDAC3 | |
| SCHEMBL21167623 | 0.82 | KDR (0.42) | NPC1KDRSYKHDAC3 | |
| SCHEMBL21167731 | 0.81 | NPC1 (0.43) | NPC1KDRRAB9AL3MBTL1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |