Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.39 |
| ▸ | CDC7 | O00311 | 5/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.39 |
| ▸ | PRKACA | P17612 | 4/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | MARK3 | P27448 | 4/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170342 | 0.83 | MAP2K4 (0.39) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL21170457 | 0.80 | JAK2 (0.40) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL12286791 | 0.80 | JAK2 (0.41) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL21170188 | 0.78 | JAK2 (0.41) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL21170165 | 0.77 | CDK2 (0.41) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL21170076 | 0.75 | CDK2 (0.40) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL12287860 | 0.74 | JAK2 (0.41) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL21170049 | 0.73 | DYRK1A (0.38) | JAK2ROCK2CDK2JAK3ROCK1 | |
| SCHEMBL21170135 | 0.73 | MAPK1 (0.38) | CDK2MAPK1 | |
| SCHEMBL12287507 | 0.72 | JAK2 (0.44) | JAK2ROCK2CDK2JAK3ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |