Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 17/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.44 |
| ▸ | AURKA | O14965 | 10/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563474 | 0.90 | PDPK1 (0.43) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL21170312 | 0.86 | ABL1 (0.47) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL12287320 | 0.83 | JAK2 (0.41) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL12287444 | 0.79 | ABL1 (0.47) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL12289987 | 0.79 | JAK2 (0.44) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL12287071 | 0.78 | PDPK1 (0.45) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL21170124 | 0.77 | ABL1 (0.37) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL12289956 | 0.74 | JAK2 (0.42) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL12287319 | 0.74 | JAK2 (0.39) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL2566819 | 0.73 | CDC7 (0.44) | PDPK1TGFBR1AURKAAURKBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |