Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 9/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018558 | 0.83 | LIMK1 (0.37) | HRH3LIMK1LIMK2MAPT | |
| SCHEMBL15626293 | 0.81 | LIMK1 (0.36) | HRH3LIMK1LIMK2MAPK14 | |
| SCHEMBL16989331 | 0.81 | LIMK1 (0.36) | HRH3LIMK1LIMK2MAPK14 | |
| SCHEMBL4020442 | 0.80 | LIMK1 (0.36) | HRH3LIMK1LIMK2 | |
| SCHEMBL4019006 | 0.78 | LIMK1 (0.37) | HRH3LIMK1LIMK2MAPTCHRNB2 | |
| SCHEMBL21170636 | 0.77 | NPC1 (0.43) | MAPTCYP2D6CYP2C9CYP2C19CYP19A1 | |
| SCHEMBL13870028 | 0.74 | HRH3 (0.36) | HRH3LIMK1LIMK2 | |
| SCHEMBL4019009 | 0.73 | LIMK1 (0.36) | LIMK1LIMK2 | |
| SCHEMBL13901881 | 0.72 | NPC1 (0.40) | LIMK1LIMK2 | |
| SCHEMBL13870032 | 0.72 | LIMK1 (0.34) | HRH3LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903436-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES | UNIV PENNSYLVANIA (US) | 2019-07-17 | — | — | EP | disclosed |