Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 4/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | BRD2 | P25440 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21172581 | 1.00 | TDP1 (0.44) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL21173200 | 0.87 | KDM4E (0.45) | KDM4EHSD17B10MAPTHPGDNOTUM | |
| SCHEMBL24347110 | 0.87 | TDP1 (0.43) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL21173212 | 0.86 | TDP1 (0.43) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL21172814 | 0.86 | TDP1 (0.43) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL21172528 | 0.85 | MAPT (0.41) | GAAPOLBMAPTHPGDNOTUM | |
| SCHEMBL21172800 | 0.84 | TDP1 (0.41) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL21172774 | 0.84 | MAPT (0.43) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL30083874 | 0.84 | TDP1 (0.41) | TDP1KDM4EGAAHSD17B10POLB | |
| SCHEMBL21173163 | 0.82 | TDP1 (0.47) | TDP1KDM4EGAAHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-B1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-03-02 | — | — | EP | disclosed |
| EP-3511323-A1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No.2) Limited (GB) | 2019-07-17 | — | — | EP | disclosed |