Known targets — ChEMBL curated mechanism
SLC6A2SLC6A3SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.43 |
| ▸ | CPT1A | P50416 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL381741 | 1.00 | CA4 (0.52) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL120392 | 1.00 | CA4 (0.52) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL22401093 | 1.00 | CA4 (0.52) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL30114648 | 1.00 | CA4 (0.52) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL120390 | 1.00 | CA4 (0.52) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL21054602 | 1.00 | CA4 (0.52) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL317390 | 0.97 | CA4 (0.50) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL28885522 | 0.97 | CA4 (0.50) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL26678179 | 0.97 | CA4 (0.50) | CA4CA2CTSLCPT2CPT1A | |
| Aspartic Acid SCHEMBL7701003 | 0.97 | CA4 (0.50) | CA4CA2CTSLCPT2CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524031-B2 | Use of a combination of D-aspartic and L-aspartic acids or salts thereof for the treatment of male infertility | MERCK SERONO S.P.A. (IT) | 2022-12-13 | — | — | US | disclosed |
| US-20190328778-A1 | USE OF A COMBINATION OF D-ASPARTIC AND L-ASPARTIC ACIDS OR SALTS THEREOF FOR THE TREATMENT OF MALE INFERTILITY | MERCK SERONO S.P.A. (IT) | 2019-10-31 | — | — | US | disclosed |
| US-10342826-B2 | Use of a combination of D-aspartic and L-aspartic acids or salts thereof for the treatment of male infertility | MERCK SERONO S.P.A. (IT) | 2019-07-09 | — | — | US | disclosed |
| US-20140271595-A1 | USE OF A COMBINATION OF D-ASPARTIC AND L-ASPARTIC ACIDS OR SALTS THEREOF FOR THE TREATMENT OF MALE INFERTILITY | MERCK SERONO S.P.A. (IT) | 2014-09-18 | — | — | US | disclosed |
| US-20120095100-A1 | USE OF A COMBINATION OF D-ASPARTIC AND L-ASPARTIC ACIDS OR SALTS THEREOF FOR THE TREATMENT OF MALE INFERTILITY | MERCK SERONO S.P.A. (IT) | 2012-04-19 | — | — | US | disclosed |