Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | SNCA | P37840 | 5/20 | 0.42 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10332221 | 0.74 | SNCA (0.49) | HSD17B10SNCARYR2LMNAHSD17B3 | |
| SCHEMBL6412235 | 0.72 | BCHE (0.52) | LMNANPC1MEN1ALDH1A1MAPT | |
| SCHEMBL17999730 | 0.64 | SNCA (0.68) | HSD17B10SNCANPC1RAB9ATP53 | |
| SCHEMBL21752052 | 0.64 | SNCA (0.68) | SNCAHSD17B3NOTUMTP53MEN1 | |
| SCHEMBL9834316 | 0.63 | HSD17B10 (0.53) | HSD17B10RYR2LMNACA1CA2 | |
| SCHEMBL7389154 | 0.63 | SNCA (0.81) | HSD17B10SNCALMNANPC1RAB9A | |
| SCHEMBL2855495 | 0.61 | KDM4E (0.55) | NPC1RAB9APARP1CA1CA2 | |
| SCHEMBL2542278 | 0.61 | HTT (0.58) | NPC1RAB9APARP1CA1CA2 | |
| SCHEMBL2835948 | 0.60 | PARP1 (0.55) | HSD17B10LMNANPC1RAB9APARP1 | |
| SCHEMBL9304654 | 0.60 | SNCA (0.49) | HSD17B10SNCARYR2LMNAHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |