Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 18/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 17/20 | 0.43 |
| ▸ | CDK2 | P24941 | 13/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.43 |
| ▸ | CDK9 | P50750 | 10/20 | 0.43 |
| ▸ | CDK7 | P50613 | 9/20 | 0.41 |
| ▸ | CCNH | P51946 | 9/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178186 | 0.88 | CCNK (0.42) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL21178469 | 0.80 | CCNK (0.56) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL21178458 | 0.79 | CCNK (0.52) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL26967451 | 0.73 | CDK7 (0.44) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL29498439 | 0.72 | CDK7 (0.42) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL21178244 | 0.72 | CCNK (0.45) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL26967517 | 0.72 | CDK7 (0.43) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL25269280 | 0.72 | CDK2 (0.47) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL25223856 | 0.72 | CCNK (0.57) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL26967465 | 0.72 | CCNK (0.53) | CCNKCDK12CDK2CCNE1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |