Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.47 |
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | CDK7 | P50613 | 6/20 | 0.47 |
| ▸ | CCNH | P51946 | 6/20 | 0.47 |
| ▸ | CCNK | O75909 | 6/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.47 |
| ▸ | CDK9 | P50750 | 4/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 12/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178277 | 0.92 | CCNE1 (0.45) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL29509162 | 0.92 | CCNE1 (0.45) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL21178397 | 0.91 | CCNK (0.45) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL21178319 | 0.90 | MAPK3 (0.38) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL21178596 | 0.89 | CCNE1 (0.45) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL21188540 | 0.86 | CCNK (0.65) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL24087396 | 0.85 | CCNK (0.42) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL29509329 | 0.85 | CCNK (0.42) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL21178811 | 0.84 | CDK7 (0.46) | CCNE1CDK2CDK7CCNHCCNK | |
| SCHEMBL21178310 | 0.84 | CDK2 (0.42) | CCNE1CDK2CDK7CCNHCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |