Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 18/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 18/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 17/20 | 0.44 |
| ▸ | CDK2 | P24941 | 17/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 16/20 | 0.44 |
| ▸ | CDK9 | P50750 | 16/20 | 0.44 |
| ▸ | CDK7 | P50613 | 9/20 | 0.44 |
| ▸ | CCNH | P51946 | 9/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509196 | 1.00 | CCNK (0.44) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509274 | 0.90 | CCNE1 (0.42) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509391 | 0.90 | CCNE1 (0.42) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509201 | 0.87 | CCNE1 (0.59) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178565 | 0.87 | CCNK (0.48) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509097 | 0.87 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509153 | 0.87 | CCNK (0.48) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509133 | 0.87 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509256 | 0.86 | CCNE1 (0.43) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509266 | 0.86 | CCNE1 (0.43) | CCNKCDK12CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |