Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2693250 | 1.00 | BTK (0.48) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL1710470 | 0.91 | BTK (0.53) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL24076244 | 0.88 | CA1 (0.47) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL20745463 | 0.85 | BTK (0.48) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL20498700 | 0.85 | BTK (0.48) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL16765432 | 0.85 | BTK (0.48) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL28279323 | 0.85 | BTK (0.58) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL14428319 | 0.85 | CA1 (0.44) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL20499274 | 0.84 | BTK (0.47) | BTKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL2694104 | 0.84 | BTK (0.47) | BTKCA1CA2HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |