Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178592 | 0.85 | PIK3CD (0.46) | PDE10APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21178426 | 0.84 | PIK3CD (0.48) | PDE10APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15818372 | 0.84 | PDE10A (0.44) | PDE10APIK3CDPIK3CBPIK3CGMEN1 | |
| SCHEMBL15818242 | 0.82 | PIK3CD (0.55) | PDE10APIK3CDPIK3CGMEN1BLM | |
| SCHEMBL15818204 | 0.80 | PDE10A (0.45) | PDE10APIK3CDPIK3CAPIK3CGMEN1 | |
| SCHEMBL21178507 | 0.80 | PIK3CD (0.45) | PDE10APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15818926 | 0.79 | PDE10A (0.48) | PDE10APIK3CDMEN1BLMKMT2A | |
| SCHEMBL16584717 | 0.79 | PDE10A (0.53) | PDE10APIK3CDALDH1A1 | |
| SCHEMBL15818416 | 0.79 | PDE10A (0.45) | PDE10APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15818773 | 0.79 | PDE10A (0.45) | PDE10APIK3CDMEN1BLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740468-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143874-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-07-25 | — | — | WO | disclosed |