Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 12/20 | 0.38 |
| ▸ | CCNH | P51946 | 12/20 | 0.38 |
| ▸ | CCNK | O75909 | 12/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 12/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.38 |
| ▸ | CDK2 | P24941 | 12/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 11/20 | 0.38 |
| ▸ | CDK9 | P50750 | 11/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178915 | 0.85 | CDK7 (0.38) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL21178695 | 0.83 | CDK7 (0.36) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL29509178 | 0.83 | CDK7 (0.36) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL29872781 | 0.83 | CDK7 (0.36) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL21178787 | 0.82 | CCNK (0.37) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL21179249 | 0.81 | CCNK (0.49) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL29509214 | 0.78 | CDK7 (0.36) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL21178547 | 0.77 | CDK7 (0.49) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL21184433 | 0.76 | CDK7 (0.55) | CDK7CCNHCCNKCDK12CCNE1 | |
| SCHEMBL21184338 | 0.76 | CDK7 (0.55) | CDK7CCNHCCNKCDK12CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |