Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 19/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 19/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.47 |
| ▸ | CDK2 | P24941 | 16/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.47 |
| ▸ | CDK9 | P50750 | 15/20 | 0.47 |
| ▸ | CDK7 | P50613 | 11/20 | 0.46 |
| ▸ | CCNH | P51946 | 11/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178451 | 0.81 | CDK7 (0.49) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21179289 | 0.81 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178204 | 0.81 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178785 | 0.81 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178522 | 0.80 | CDK7 (0.53) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178725 | 0.79 | CCNK (0.46) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178186 | 0.77 | CCNK (0.42) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178469 | 0.72 | CCNK (0.56) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24176251 | 0.71 | CCNK (0.73) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21184494 | 0.70 | CCNK (0.70) | CCNKCDK12CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740206-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |