Sugi Predict

Sugi Predict / Compounds / SCHEMBL21178933

SCHEMBL21178933

SCHEMBL21178933

Nc1ncnc2c1c(-c1cc(C3CC3)on1)cn2[C@H]1C[C@H](CO)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 17/20 1.00
▸ ABL1 P00519 2/20 0.58
▸ IGF1R P08069 2/20 0.58
▸ JAK2 O60674 1/20 0.58
▸ NTRK1 P04629 1/20 0.58
▸ INSR P06213 1/20 0.58
▸ LCK P06239 1/20 0.58
▸ NPM1 P06748 1/20 0.58
▸ CSF1R P07333 1/20 0.58
▸ LYN P07948 1/20 0.58
▸ MET P08581 1/20 0.58
▸ PDGFRB P09619 1/20 0.58
▸ KIT P10721 1/20 0.58
▸ BCR P11274 1/20 0.58
▸ FGFR1 P11362 1/20 0.58
▸ SRC P12931 1/20 0.58
▸ PDGFRA P16234 1/20 0.58
▸ FLT1 P17948 1/20 0.58
▸ FGFR2 P21802 1/20 0.58
▸ FGFR4 P22455 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21178877 1.00 RET (1.00) RETABL1IGF1RJAK2NTRK1
SCHEMBL21178847 1.00 RET (1.00) RETABL1IGF1RJAK2NTRK1
SCHEMBL22604887 1.00 RET (1.00) RETABL1IGF1RJAK2NTRK1
SCHEMBL21178849 0.87 RET (1.00) RETSRCNEK7
SCHEMBL21187718 0.85 RET (1.00) RETABL1SRCEGFRABL2
SCHEMBL21178797 0.85 RET (1.00) RETABL1IGF1RJAK2NTRK1
SCHEMBL21187589 0.84 RET (1.00) RETKDRNEK7
SCHEMBL30175194 0.84 RET (1.00) RETKDRNEK7
SCHEMBL21187717 0.83 RET (1.00) RETLCKSRCNEK7
SCHEMBL30175197 0.83 RET (1.00) RETLCKSRCNEK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11603374-B2 Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-03-14 — — US disclosed
EP-3740491-A1 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS Array Biopharma, Inc. (US) 2020-11-25 — — EP disclosed
CN-111971286-A Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors 阿雷生物药品公司 2020-11-20 — — CN disclosed
US-20200339589-A1 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2020-10-29 — — US disclosed
US-20200339589-A1 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2020-10-29 — — US disclosed
WO-2019143977-A1 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2019-07-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339589-A1 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, FGFR3 RET 1/4885ABL1 116/4885IGF1R 539/4885
US-11603374-B2 Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors RET, ROR1, FGFR3 RET 1/4885ABL1 116/4885IGF1R 539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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