Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.46 |
| ▸ | TSHR | P16473 | 10/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.46 |
| ▸ | USP2 | O75604 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21179163 | 0.89 | RET (0.60) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21179084 | 0.86 | CYP1A2 (0.51) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL28463627 | 0.82 | CYP1A2 (0.43) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178952 | 0.79 | RET (0.57) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178998 | 0.79 | RET (0.43) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178913 | 0.79 | RET (0.58) | RETCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL21179165 | 0.79 | RET (0.58) | RETCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29897201 | 0.79 | RET (0.58) | RETCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL21179022 | 0.78 | RET (0.48) | RETCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL21178980 | 0.77 | RET (0.60) | RETCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11472802-B2 | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2022-10-18 | — | — | US | disclosed |
| EP-3740486-A1 | SUBSTITUTED PYRAZOLYL[4,3-C]PYRIDINECOMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| US-20200339579-A1 | SUBSTITUTED PYRAZOLYL[4,3-C]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2020-10-29 | — | — | US | disclosed |
| WO-2019143994-A1 | SUBSTITUTED PYRAZOLYL[4,3-C]PYRIDINECOMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339579-A1 | SUBSTITUTED PYRAZOLYL[4,3-C]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | RET 1/4885CYP1A2 3855/4885CYP3A4 3471/4885 |
| US-11472802-B2 | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | RET 1/4885CYP1A2 3855/4885CYP3A4 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.