Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 19/20 | 0.54 |
| ▸ | CDK12 | Q9NYV4 | 18/20 | 0.54 |
| ▸ | CDK2 | P24941 | 14/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 11/20 | 0.54 |
| ▸ | CDK9 | P50750 | 11/20 | 0.54 |
| ▸ | CDK7 | P50613 | 7/20 | 0.53 |
| ▸ | CCNH | P51946 | 7/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509346 | 1.00 | CCNK (0.54) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL21178843 | 0.90 | CCNK (0.59) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL21188565 | 0.87 | CCNK (0.54) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL25597338 | 0.86 | CDK7 (0.59) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL30439510 | 0.86 | CCNK (0.67) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL21178767 | 0.86 | CCNK (0.67) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL25595573 | 0.86 | CCNK (0.67) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL25593060 | 0.85 | CDK2 (0.60) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL30204027 | 0.85 | CCNK (0.72) | CCNKCDK12CDK2CCNE1CCNT1 | |
| SCHEMBL30204021 | 0.85 | CCNK (0.62) | CCNKCDK12CDK2CCNE1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |