Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 6/20 | 0.40 |
| ▸ | CCNH | P51946 | 6/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.40 |
| ▸ | CDK9 | P50750 | 5/20 | 0.40 |
| ▸ | SYK | P43405 | 8/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 4/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24176326 | 0.90 | CDK7 (0.42) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21184310 | 0.88 | CDK7 (0.43) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21178909 | 0.88 | CDK7 (0.44) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21179220 | 0.88 | CDK7 (0.37) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL24176252 | 0.88 | CCNK (0.43) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21184297 | 0.88 | CDK7 (0.44) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21184414 | 0.88 | CDK7 (0.42) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21184569 | 0.87 | CDK7 (0.38) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21184448 | 0.85 | CDK7 (0.38) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL21184311 | 0.84 | CDK7 (0.50) | CDK7CCNHMNAT1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |