SCHEMBL21184374 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	CCNK	O75909	16/20	0.78

▸	CDK12	Q9NYV4	16/20	0.78

▸	CCNT1	O60563	15/20	0.78

▸	CCNE1	P24864	15/20	0.78

▸	CDK2	P24941	15/20	0.78

▸	CDK9	P50750	15/20	0.78

▸	CDK7	P50613	12/20	0.78

▸	CCNH	P51946	12/20	0.78

▸	MNAT1	P51948	7/20	0.78

▸	CYP2D6	P10635	1/20	0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30006623	0.93	CCNK (0.77)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL28817251	0.93	CCNK (0.77)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL28817252	0.93	CCNK (0.77)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL30006346	0.93	CDK7 (0.75)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL28817270	0.93	CDK7 (0.75)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL24589005	0.92	CCNK (0.72)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL24588249	0.92	CCNK (0.80)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL24588868	0.92	CCNK (0.71)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL24588867	0.92	CCNK (0.71)	CCNKCDK12CCNT1CCNE1CDK2
SCHEMBL28817405	0.92	CCNK (0.71)	CCNKCDK12CCNT1CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2019143730-A1	INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)	SYROS PHARMACEUTICALS, INC. (US)	2019-07-25	—	—	WO	disclosed