Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 13/20 | 0.53 |
| ▸ | CCNH | P51946 | 13/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 12/20 | 0.53 |
| ▸ | CCNK | O75909 | 12/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 12/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.51 |
| ▸ | CDK9 | P50750 | 8/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.51 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184593 | 0.98 | CDK7 (0.53) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21184416 | 0.89 | CDK7 (0.49) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21184597 | 0.89 | CDK7 (0.45) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL24176320 | 0.89 | CDK7 (0.45) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL24176265 | 0.89 | CDK7 (0.45) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21184557 | 0.89 | CDK7 (0.51) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21184417 | 0.89 | CCNK (0.46) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL30204135 | 0.89 | CDK7 (0.62) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL25601729 | 0.89 | CDK7 (0.62) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL24176230 | 0.88 | CDK7 (0.44) | CDK7CCNHMNAT1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |