Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 11/20 | 0.44 |
| ▸ | CCNH | P51946 | 11/20 | 0.44 |
| ▸ | CCNK | O75909 | 8/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.44 |
| ▸ | CDK9 | P50750 | 7/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.36 |
| ▸ | BRD4 | O60885 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30771923 | 1.00 | CDK7 (0.44) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL21178765 | 1.00 | CDK7 (0.44) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL27162475 | 1.00 | CDK7 (0.44) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL30771938 | 0.96 | CDK7 (0.42) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176435 | 0.93 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL21184435 | 0.93 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176256 | 0.93 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176293 | 0.93 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176338 | 0.93 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL21184601 | 0.93 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |