Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 14/20 | 0.66 |
| ▸ | CDK12 | Q9NYV4 | 14/20 | 0.66 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.66 |
| ▸ | CDK2 | P24941 | 13/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 12/20 | 0.66 |
| ▸ | CDK9 | P50750 | 12/20 | 0.66 |
| ▸ | CDK7 | P50613 | 6/20 | 0.66 |
| ▸ | CCNH | P51946 | 6/20 | 0.66 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184546 | 0.90 | CCNK (0.64) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21184404 | 0.84 | CCNK (0.85) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24176255 | 0.82 | CCNK (0.72) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21184518 | 0.81 | CCNK (0.73) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188311 | 0.80 | CCNK (1.00) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188507 | 0.80 | CCNK (1.00) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24176439 | 0.80 | CCNK (0.69) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21184521 | 0.80 | CCNK (0.78) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24176432 | 0.80 | CCNK (0.69) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188585 | 0.80 | CCNK (0.78) | CCNKCDK12CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |