Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 16/20 | 0.72 |
| ▸ | CDK12 | Q9NYV4 | 16/20 | 0.72 |
| ▸ | CDK9 | P50750 | 16/20 | 0.72 |
| ▸ | CDK2 | P24941 | 15/20 | 0.72 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.72 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.72 |
| ▸ | CDK7 | P50613 | 13/20 | 0.72 |
| ▸ | CCNH | P51946 | 12/20 | 0.72 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184600 | 0.95 | CCNK (0.72) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL21184573 | 0.91 | CCNK (0.72) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL24176489 | 0.91 | CCNK (0.74) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL21184362 | 0.90 | CCNK (0.71) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL21184615 | 0.90 | CCNK (0.85) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL21184360 | 0.89 | CCNK (0.69) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL21184364 | 0.89 | CCNK (0.69) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL21184429 | 0.89 | CCNK (0.69) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL30771949 | 0.89 | CCNK (0.69) | CCNKCDK12CDK9CDK2CCNT1 | |
| SCHEMBL30771916 | 0.89 | CCNK (0.69) | CCNKCDK12CDK9CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |