Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 18/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 18/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.51 |
| ▸ | CDK2 | P24941 | 16/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 14/20 | 0.51 |
| ▸ | CDK9 | P50750 | 14/20 | 0.51 |
| ▸ | CDK7 | P50613 | 10/20 | 0.51 |
| ▸ | CCNH | P51946 | 10/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24087380 | 1.00 | CCNK (0.51) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188571 | 0.86 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188592 | 0.84 | CCNK (0.64) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21179179 | 0.84 | CCNK (0.54) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21179184 | 0.84 | CCNK (0.54) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24087252 | 0.77 | CCNK (0.70) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188575 | 0.76 | RXFP1 (0.30) | — | |
| SCHEMBL24087469 | 0.76 | CCNK (0.55) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24087399 | 0.75 | — | — | |
| SCHEMBL21188146 | 0.72 | CCNK (0.76) | CCNKCDK12CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |