Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178841 | 0.87 | LRRK2 (0.30) | LRRK2 | |
| SCHEMBL21178278 | 0.78 | BRD4 (0.35) | — | |
| SCHEMBL21188574 | 0.78 | AR (0.32) | ESR1ESR2 | |
| SCHEMBL21179061 | 0.77 | MAPT (0.33) | ESR1ESR2MAPK1 | |
| SCHEMBL21178901 | 0.75 | AXL (0.36) | — | |
| SCHEMBL21178477 | 0.74 | BRD4 (0.41) | ESR1ESR2MAPK1 | |
| SCHEMBL24087353 | 0.73 | JAK2 (0.42) | MAPK1 | |
| SCHEMBL14814136 | 0.71 | FGFR1 (0.44) | GSK3AGSK3BESR1ESR2 | |
| SCHEMBL7926347 | 0.69 | ADORA1 (0.48) | — | |
| SCHEMBL14814114 | 0.69 | ESR1 (0.40) | GSK3AGSK3BESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |