Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212187 | 0.92 | CNR1 (0.37) | CNR1CNR2CFTRPPARATYRO3 | |
| SCHEMBL14856733 | 0.88 | CNR1 (0.43) | CNR1TRPV1SCN9ACNR2PPARA | |
| SCHEMBL212570 | 0.88 | CNR1 (0.61) | CNR1CNR2CFTR | |
| SCHEMBL10031418 | 0.88 | CNR1 (0.61) | CNR1CNR2CFTR | |
| SCHEMBL10031414 | 0.88 | CNR1 (0.61) | CNR1CNR2CFTR | |
| SCHEMBL212749 | 0.87 | MEN1 (0.41) | CNR1TRPV1CNR2CFTRPPARA | |
| SCHEMBL213908 | 0.87 | NPY2R (0.37) | CNR1TRPV1CNR2CFTRPPARA | |
| SCHEMBL4064887 | 0.85 | CNR1 (0.44) | CNR1TRPV1CNR2EDNRA | |
| SCHEMBL212569 | 0.84 | CNR1 (0.54) | CNR1CNR2CFTR | |
| SCHEMBL212545 | 0.82 | CNR1 (0.53) | CNR1CNR2CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | claimed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | disclosed |