Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25121988 | 0.89 | CYP3A4 (0.46) | CYP3A4CYP1A2CYP2D6CHRM2CHRM4 | |
| SCHEMBL739693 | 0.88 | HRH3 (0.41) | HRH3SMN1; SMN2CHRM3 | |
| SCHEMBL12156766 | 0.85 | HRH3 (0.38) | HRH3 | |
| SCHEMBL18313883 | 0.85 | HRH3 (0.38) | HRH3 | |
| SCHEMBL19175355 | 0.83 | — | — | |
| SCHEMBL25005192 | 0.82 | HRH3 (0.35) | HRH3CYP3A4CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL19123527 | 0.82 | HRH3 (0.35) | HRH3CYP3A4CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL25567959 | 0.81 | PARP1 (0.32) | HRH3PARP1 | |
| SCHEMBL17306143 | 0.79 | HRH3 (0.31) | HRH3 | |
| SCHEMBL21421672 | 0.78 | HRH3 (0.36) | HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019144117-A1 | BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT | BIOVENTURES, LLC (US) | 2019-07-25 | — | — | WO | disclosed |