Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | MST1R | Q04912 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.41 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29867145 | 1.00 | CDK5 (0.56) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL21349617 | 0.93 | CDK5 (0.53) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL31289384 | 0.90 | CDK5 (0.50) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL31289326 | 0.84 | CDK5 (0.47) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL31289320 | 0.76 | KDM4E (0.49) | — | |
| SCHEMBL1335497 | 0.76 | DYRK1A (0.61) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL29532218 | 0.73 | PARP1 (0.70) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL6297545 | 0.73 | PARP1 (0.70) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL29867664 | 0.72 | CDK5 (0.41) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL24148319 | 0.72 | CDK5 (0.61) | CDK5DYRK1ACLK4PIM1CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |