Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 20/20 | 0.68 |
| ▸ | CBLC | Q9ULV8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21200466 | 1.00 | CBLB (0.68) | CBLBCBLC | |
| SCHEMBL29866740 | 1.00 | CBLB (0.68) | CBLBCBLC | |
| SCHEMBL21200018 | 1.00 | CBLB (0.68) | CBLBCBLC | |
| SCHEMBL29867023 | 1.00 | CBLB (0.68) | CBLBCBLC | |
| SCHEMBL26918903 | 0.87 | CBLB (0.55) | CBLBCBLC | |
| SCHEMBL29998030 | 0.87 | CBLB (0.55) | CBLBCBLC | |
| SCHEMBL29998936 | 0.87 | CBLB (0.55) | CBLBCBLC | |
| SCHEMBL26918905 | 0.87 | CBLB (0.55) | CBLBCBLC | |
| SCHEMBL29997890 | 0.85 | CBLB (0.59) | CBLBCBLC | |
| SCHEMBL26922440 | 0.85 | CBLB (0.59) | CBLBCBLC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |