Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | NMT1 | P30419 | 10/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21208130 | 0.88 | CDK2 (0.48) | ALDH1A1POLBGAAMAPTNCOA1 | |
| SCHEMBL21217063 | 0.86 | PRKDC (0.52) | CSNK1EALDH1A1POLBGAAMAPT | |
| SCHEMBL21209372 | 0.85 | CSNK1E (0.49) | CSNK1ENMT1KARS1DYRK1ATLR9 | |
| SCHEMBL24688736 | 0.82 | CSNK1E (0.56) | CSNK1ENMT1KARS1DYRK1ATLR9 | |
| SCHEMBL21217032 | 0.80 | IRAK4 (0.57) | CSNK1EALDH1A1POLBGAAMAPT | |
| SCHEMBL21208144 | 0.78 | CDK2 (0.59) | ALDH1A1POLBGAAMAPTNCOA1 | |
| SCHEMBL7965088 | 0.75 | CDK2 (0.54) | ALDH1A1POLBGAAMAPTNCOA1 | |
| SCHEMBL21209364 | 0.74 | DRD1 (0.41) | CSNK1EGAAMAPTNMT1CDK2 | |
| SCHEMBL3442456 | 0.73 | DYRK1A (0.64) | NMT1KARS1DYRK1APLD1 | |
| SCHEMBL9968482 | 0.72 | MEN1 (0.52) | ALDH1A1GAANMT1KARS1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148136-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |