Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119854 | 0.80 | — | — | |
| SCHEMBL18850230 | 0.78 | CRBN (0.36) | CRBNTAS2R38 | |
| SCHEMBL21208236 | 0.76 | CRBN (0.35) | CRBNTAS2R38 | |
| SCHEMBL11019175 | 0.75 | CRBN (0.50) | CRBNTAS2R38TDP1LMNAALOX15 | |
| SCHEMBL21210763 | 0.73 | CRBN (0.32) | CRBNTAS2R38 | |
| SCHEMBL14543081 | 0.72 | — | — | |
| SCHEMBL3506421 | 0.72 | CRBN (0.39) | CRBNTAS2R38 | |
| SCHEMBL4378123 | 0.72 | CRBN (0.39) | CRBNTAS2R38 | |
| SCHEMBL3506422 | 0.72 | CRBN (0.39) | CRBNTAS2R38 | |
| SCHEMBL13788471 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148132-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |
| WO-2019148136-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |