Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 18/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21210219 | 0.90 | EIF2AK4 (0.56) | EIF2AK4 | |
| SCHEMBL21209210 | 0.89 | EIF2AK4 (0.55) | EIF2AK4 | |
| SCHEMBL21209200 | 0.89 | EIF2AK4 (0.55) | EIF2AK4 | |
| SCHEMBL21209911 | 0.88 | IRAK4 (0.49) | EIF2AK4IRAK4CYP1A2CYP2C9 | |
| SCHEMBL21209470 | 0.84 | EIF2AK4 (0.71) | EIF2AK4 | |
| SCHEMBL21209209 | 0.84 | EIF2AK4 (0.54) | EIF2AK4CYP1A2 | |
| SCHEMBL21217128 | 0.83 | EIF2AK4 (0.70) | EIF2AK4 | |
| SCHEMBL21209521 | 0.83 | EIF2AK4 (0.53) | EIF2AK4 | |
| SCHEMBL21208913 | 0.82 | EIF2AK4 (0.58) | EIF2AK4 | |
| SCHEMBL21210207 | 0.81 | EIF2AK4 (0.54) | EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148132-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |