Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.57 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34462903 | 0.85 | GAA (0.56) | GAAHPGDGRM5MEN1MAPK1 | |
| SCHEMBL34462958 | 0.85 | GAA (0.56) | GAAHPGDGRM5MEN1MAPK1 | |
| SCHEMBL23029632 | 0.84 | PROKR1 (0.49) | GAAHPGDPROKR1GRM5PDK2 | |
| SCHEMBL30009291 | 0.82 | HPGD (0.64) | GAAHPGDGRM5MEN1MAPK1 | |
| SCHEMBL23029422 | 0.82 | PROKR1 (0.47) | GAAHPGDPROKR1GRM5CA12 | |
| SCHEMBL22055721 | 0.81 | GAA (0.71) | GAAHPGDCA12CA1CA2 | |
| SCHEMBL5908997 | 0.81 | GAA (0.71) | GAAHPGDCA12CA1CA2 | |
| SCHEMBL1948862 | 0.80 | PROKR1 (0.46) | GAAHPGDPROKR1HTTALDH1A1 | |
| SCHEMBL4520736 | 0.80 | HPGD (0.60) | GAAHPGDGRM5MEN1MAPK1 | |
| SCHEMBL18114799 | 0.79 | PROKR1 (0.50) | PROKR1GRM5PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |