Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.42 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.42 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16920715 | 0.97 | ESR1 (0.47) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL19820045 | 0.96 | MAPK1 (0.46) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL23031881 | 0.92 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL17519161 | 0.92 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL22639113 | 0.92 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL17974033 | 0.92 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL18610577 | 0.92 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL17359466 | 0.91 | ESR1 (0.56) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL21207336 | 0.90 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 | |
| SCHEMBL21086224 | 0.90 | MAPK1 (0.48) | MAPK1ESR1PGRHTR1AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370668-B2 | Manufacture of antisense oligomers and conjugates targeting PCSK9 | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2019-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370668-B2 | Manufacture of antisense oligomers and conjugates targeting PCSK9 | PCSK9, PCSK7, PCSK6 | MAPK1 3652/4885ESR1 4248/4885PGR 4808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.