Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 7/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21229320 | 0.94 | SCN9A (0.37) | NTRK1SCN9AJAK2CCNT1CDK9 | |
| SCHEMBL16936088 | 0.81 | NTRK1 (0.44) | NTRK1SCN9AJAK2CSNK2A1AXL | |
| SCHEMBL21229318 | 0.81 | NTRK1 (0.38) | NTRK1JAK2 | |
| SCHEMBL16936008 | 0.79 | NTRK1 (0.43) | NTRK1SCN9AJAK2AXLBRD4 | |
| SCHEMBL21229249 | 0.78 | PCSK9 (0.45) | NTRK1SCN9ACCNT1CDK9AXL | |
| SCHEMBL21229319 | 0.76 | NTRK1 (0.43) | NTRK1JAK2 | |
| SCHEMBL16946989 | 0.74 | NTRK1 (0.40) | NTRK1SCN9AJAK2AXLBRD4 | |
| SCHEMBL16946998 | 0.73 | NTRK1 (0.43) | NTRK1SCN9AJAK2 | |
| SCHEMBL16946991 | 0.73 | NTRK1 (0.39) | NTRK1SCN9AJAK2CSNK2A1AXL | |
| SCHEMBL16946993 | 0.72 | NTRK1 (0.39) | NTRK1SCN9AJAK2CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019149131-A1 | COMPOUND HAVING MACROCYCLIC MOLECULAR STRUCTURE AND USE THEREOF | 上海吉倍生物技术有限公司 | 2019-08-08 | — | — | WO | disclosed |