Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSC | P53634 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26079728 | 0.89 | PREP (0.43) | PREPDPP4USP30AAK1P2RX7 | |
| SCHEMBL21233252 | 0.89 | PREP (0.41) | PREPDPP4CHRM2CHRM1CHRM3 | |
| SCHEMBL18643728 | 0.88 | PREP (0.42) | PREPDPP4USP30AAK1P2RX7 | |
| SCHEMBL16064115 | 0.88 | PREP (0.42) | PREPDPP4USP30AAK1P2RX7 | |
| SCHEMBL22642902 | 0.87 | CTSC (0.46) | CTSKCTSC | |
| SCHEMBL16064313 | 0.87 | CTSC (0.46) | CTSKCTSC | |
| SCHEMBL16064323 | 0.87 | CTSC (0.46) | CTSKCTSC | |
| SCHEMBL21172930 | 0.85 | PREP (0.40) | PREPDPP4USP30AAK1P2RX7 | |
| SCHEMBL16078799 | 0.81 | PREP (0.40) | PREPDPP4USP30AAK1CHRM2 | |
| SCHEMBL22642842 | 0.81 | PREP (0.40) | PREPDPP4USP30AAK1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191487-B1 | SPIROCYCLIC INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2019-08-07 | — | — | EP | disclosed |