Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.64 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | SPR | P35270 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 5/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18705165 | 0.84 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3SPRRET | |
| SCHEMBL21234082 | 0.83 | GRIN2B (0.48) | GRIN2BGRIN2CJAK3SPRRET | |
| SCHEMBL21234076 | 0.83 | GRIN2B (0.48) | GRIN2BGRIN2CJAK3SPRRET | |
| SCHEMBL21233783 | 0.83 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3 | |
| SCHEMBL21234069 | 0.82 | GRIN2B (0.45) | GRIN2BGRIN2CJAK3 | |
| SCHEMBL21234128 | 0.81 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3SPRRET | |
| SCHEMBL18705161 | 0.80 | JAK3 (0.44) | GRIN2BGRIN2CJAK3SPRRET | |
| SCHEMBL18705173 | 0.80 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3SPRRET | |
| SCHEMBL18705167 | 0.79 | GRIN2B (0.45) | GRIN2BGRIN2CJAK3SPRRET | |
| Zelquistinel SCHEMBL24636775 | 0.78 | GRIN2B (1.00) | GRIN2BGRIN2CJAK3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152696-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |