Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 4/20 | 0.56 |
| ▸ | PDE1A | P54750 | 2/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.56 |
| ▸ | PDE4A | P27815 | 12/20 | 0.47 |
| ▸ | PDE2A | O00408 | 3/20 | 0.47 |
| ▸ | PDE8A | O60658 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193938 | 0.92 | PDE1B (0.66) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL2119817 | 0.90 | PDE1B (0.56) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL2121446 | 0.89 | PDE1B (0.55) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL2612339 | 0.89 | PDE1B (0.55) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL2121444 | 0.89 | PDE1B (0.55) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL8045653 | 0.85 | PDE1B (0.59) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL194834 | 0.85 | PDE1B (0.58) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL194833 | 0.85 | PDE1B (0.58) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL3008702 | 0.85 | PDE1B (0.58) | PDE1BPDE1APDE1CPDE4APDE2A | |
| SCHEMBL3008705 | 0.85 | PDE1B (0.58) | PDE1BPDE1APDE1CPDE4APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367431-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-20140315868-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-10-23 | — | — | US | disclosed |
| US-8697710-B2 | Optionally substituted 3-amino-4-(thioxo or imino)-4,5-dihydro-2H-pyrazolo [3,4-d]pyrimidin-6(7H)-ones | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20120094966-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2012-04-19 | — | — | US | disclosed |
| EP-2367431-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065153-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315868-A1 | ORGANIC COMPOUNDS | TPMT, CYP4X1, P2RX4 | PDE1B 4847/4885PDE1A 4868/4885PDE1C 4824/4885 |
| US-20120094966-A1 | ORGANIC COMPOUNDS | TPMT, CYP4X1, P2RX4 | PDE1B 4847/4885PDE1A 4868/4885PDE1C 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.