Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122319 | 0.92 | S1PR1 (0.53) | S1PR1 | |
| SCHEMBL2124789 | 0.89 | S1PR1 (0.50) | S1PR1S1PR5 | |
| SCHEMBL2122241 | 0.88 | S1PR1 (0.51) | S1PR1XDHS1PR5 | |
| SCHEMBL2123543 | 0.87 | S1PR1 (0.53) | S1PR1XDHS1PR5 | |
| SCHEMBL2123484 | 0.84 | S1PR1 (0.63) | S1PR1S1PR5 | |
| SCHEMBL14018919 | 0.84 | S1PR1 (0.59) | S1PR1XDHS1PR5 | |
| SCHEMBL2122315 | 0.79 | S1PR1 (0.52) | S1PR1XDH | |
| SCHEMBL2125906 | 0.77 | S1PR1 (0.67) | S1PR1 | |
| SCHEMBL2117585 | 0.77 | S1PR1 (0.72) | S1PR1S1PR5 | |
| SCHEMBL2122240 | 0.77 | S1PR1 (0.48) | S1PR1XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443110-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| EP-2443112-A1 | THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145202-A1 | THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010146105-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |