Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | XIAP | P98170 | 6/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 6/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | CASP2 | P42575 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612565 | 0.91 | NOTUM (0.51) | NOTUMXIAPBIRC2SLC18A3SIGMAR1 | |
| SCHEMBL2126408 | 0.85 | KDM1A (0.36) | NOTUMXIAPBIRC2 | |
| SCHEMBL23671532 | 0.83 | PIK3CA (0.42) | NOTUMXIAPBIRC2HSD17B3ALDH1A1 | |
| SCHEMBL17436116 | 0.79 | NOTUM (0.63) | NOTUMXIAPBIRC2HSD17B3LMNA | |
| SCHEMBL2126993 | 0.77 | PIK3CA (0.46) | ALDH1A1 | |
| SCHEMBL1613196 | 0.77 | NOTUM (0.47) | NOTUMXIAPBIRC2HSD17B3CASP2 | |
| SCHEMBL17436040 | 0.77 | NOTUM (0.65) | NOTUMXIAPBIRC2HSD17B3ALDH1A1 | |
| SCHEMBL15401238 | 0.76 | NOTUM (0.47) | NOTUMXIAPBIRC2HSD17B3ALDH1A1 | |
| SCHEMBL1830230 | 0.74 | XIAP (0.43) | XIAPBIRC2HSD17B3ALDH1A1POLB | |
| SCHEMBL2125253 | 0.74 | NOTUM (0.52) | NOTUMXIAPBIRC2HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765940-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120094972-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094972-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | NOTUM 4008/4885XIAP 202/4885BIRC2 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.