Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CBLB | Q13191 | 1/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662750 | 0.84 | NT5E (0.65) | GFERABL1KMT2ABRAFNPC1 | |
| SCHEMBL7118764 | 0.82 | ABL1 (0.59) | GFERABL1KMT2AACP1ROCK1 | |
| SCHEMBL19663327 | 0.82 | ABL1 (0.59) | GFERABL1KMT2AACP1RAB9A | |
| SCHEMBL21237217 | 0.81 | HDAC8 (0.59) | GFERABL1KMT2ATP53ROCK1 | |
| SCHEMBL12057348 | 0.81 | NT5E (0.67) | KMT2ABRAFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3380451 | 0.81 | MAPT (0.63) | ABL1KMT2AACP1RAB9ASMN1; SMN2 | |
| SCHEMBL23844170 | 0.79 | NPC1 (0.76) | KMT2ABRAFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22661803 | 0.79 | CYP3A4 (0.64) | ABL1KMT2AROCK1TDP1PORCN | |
| SCHEMBL25135525 | 0.79 | ABL1 (0.71) | ABL1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12017613 | 0.78 | BRAF (0.79) | KMT2ABRAFNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247989-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2022-02-15 | — | — | US | disclosed |
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247989-B2 | Therapeutic compounds and uses thereof | EP300, HDAC1, CREBBP | GFER 4358/4885ABL1 519/4885KMT2A 254/4885 |
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, CREBBP | GFER 4358/4885ABL1 519/4885KMT2A 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.