Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 13/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21237392 | 0.88 | CREBBP (0.51) | CREBBPDGAT2NOTUM | |
| SCHEMBL21237196 | 0.88 | CREBBP (0.51) | CREBBPNOTUM | |
| SCHEMBL21237201 | 0.88 | CREBBP (0.51) | CREBBPNOTUM | |
| SCHEMBL21237243 | 0.82 | CREBBP (0.43) | CREBBP | |
| SCHEMBL21237241 | 0.82 | CREBBP (0.43) | CREBBPCLK2LRRK2KCNH2SCN5A | |
| SCHEMBL21237247 | 0.82 | CREBBP (0.43) | CREBBP | |
| SCHEMBL21237185 | 0.79 | CREBBP (0.46) | CREBBPLRRK2 | |
| SCHEMBL21237184 | 0.79 | CREBBP (0.46) | CREBBPLRRK2 | |
| SCHEMBL21237469 | 0.79 | HRH4 (0.46) | CREBBP | |
| SCHEMBL21237249 | 0.79 | HRH4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, CREBBP | CREBBP 3/4885RBP4 2680/4885DGAT2 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.