SCHEMBL21240407

[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])c(Cl)c(-c2cc3cnc(Nc4c(C)cccc4NC(=O)C=C)nc3c(NCC3CC3)n2)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	FGFR1	P11362	17/20	0.61

▸	FGFR4	P22455	12/20	0.56

▸	FGFR2	P21802	2/20	0.56

▸	FGFR3	P22607	2/20	0.56

▸	CYP1A2	P05177	1/20	0.56

▸	CSF1R	P07333	1/20	0.56

▸	CYP3A4	P08684	1/20	0.56

▸	CYP2D6	P10635	1/20	0.56

▸	CYP2C9	P11712	1/20	0.56

▸	CYP2C19	P33261	1/20	0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29577694	0.95	FGFR1 (0.68)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL20331614	0.95	FGFR1 (0.68)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL29578018	0.93	FGFR1 (0.66)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL20332274	0.93	FGFR1 (0.66)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL21240560	0.92	FGFR1 (0.54)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL29577335	0.91	FGFR1 (0.64)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL20330763	0.91	FGFR1 (0.64)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL30045089	0.90	FGFR1 (0.63)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL20331520	0.90	FGFR1 (0.63)	FGFR1FGFR4FGFR2FGFR3CYP1A2
SCHEMBL29579139	0.90	FGFR1 (0.65)	FGFR1FGFR4FGFR2FGFR3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3524603-A1	FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF	Abbisko Therapeutics Co., Ltd. (CN)	2019-08-14	—	—	EP	disclosed