Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 18/20 | 0.53 |
| ▸ | EP300 | Q09472 | 17/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17868650 | 0.78 | CREBBP (0.43) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL4761723 | 0.77 | CREBBP (0.47) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL17785865 | 0.74 | CREBBP (0.44) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL17785675 | 0.74 | CREBBP (0.47) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL5953472 | 0.74 | HCAR2 (0.56) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL20818349 | 0.74 | CREBBP (0.44) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL1006514 | 0.73 | DPP4 (0.50) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL17846631 | 0.73 | CREBBP (0.84) | CREBBPEP300BRD4 | |
| SCHEMBL18586765 | 0.71 | CREBBP (0.45) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL5645375 | 0.71 | DPP4 (0.52) | CREBBPEP300BRD4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-B1 | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH INC (US) | 2019-08-14 | — | — | EP | disclosed |