Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241286 | 1.00 | IRAK4 (0.38) | IRAK4IRAK1KDRVHL | |
| SCHEMBL22701760 | 0.87 | IRAK4 (0.39) | IRAK4IRAK1KDRVHL | |
| SCHEMBL22701762 | 0.87 | IRAK4 (0.39) | IRAK4IRAK1KDRVHL | |
| SCHEMBL23946100 | 0.86 | IRAK4 (0.38) | IRAK4IRAK1KDRVHL | |
| SCHEMBL17137284 | 0.86 | IRAK4 (0.38) | IRAK4IRAK1KDRVHL | |
| SCHEMBL17142223 | 0.86 | IRAK4 (0.38) | IRAK4IRAK1KDRVHL | |
| SCHEMBL29900220 | 0.86 | IRAK4 (0.36) | IRAK4IRAK1KDRVHL | |
| SCHEMBL17137407 | 0.86 | IRAK4 (0.38) | IRAK4IRAK1KDRVHL | |
| SCHEMBL17137499 | 0.86 | IRAK4 (0.38) | IRAK4IRAK1KDRVHL | |
| SCHEMBL22259095 | 0.82 | IRAK4 (0.43) | IRAK4IRAK1KDRVHL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019149522-A1 | QUINOLINE COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-08 | — | — | WO | disclosed |