Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PTPRB | P23467 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225195 | 0.90 | SCN9A (0.54) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224256 | 0.90 | HDAC3 (0.54) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21225194 | 0.90 | SCN9A (0.54) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224257 | 0.90 | HDAC3 (0.54) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL8076879 | 0.89 | HDAC1 (0.60) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224490 | 0.88 | HDAC4 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224487 | 0.88 | HDAC4 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224274 | 0.88 | CAPN1 (0.55) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224273 | 0.88 | CAPN1 (0.55) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL21224246 | 0.88 | HDAC4 (0.54) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |