Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.65 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16092103 | 0.82 | MAPK14 (0.70) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL17728180 | 0.81 | MAPK14 (0.61) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL16092101 | 0.80 | MAPK14 (0.66) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL16062323 | 0.80 | MAPK14 (0.66) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL16092113 | 0.79 | MAPK14 (1.00) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL16060785 | 0.79 | MAPK14 (0.65) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL30360182 | 0.76 | MAPK14 (0.76) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL21219601 | 0.76 | MAPK14 (0.76) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL16092092 | 0.75 | MAPK14 (0.60) | MAPK14MAPK11KDRCSNK1DKDM4E | |
| SCHEMBL30756642 | 0.74 | TNF (0.63) | MAPK14MAPK11KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521284-A1 | PYRAZINE COMPOUNDS AS MAP KINASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2019-08-07 | — | — | EP | disclosed |