Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Benoxinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 5/20 | 0.98 |
| ▸ | SCN2A known ✓ | Q99250 | 5/20 | 0.98 |
| ▸ | SCN3A known ✓ | Q9NY46 | 5/20 | 0.98 |
| ▸ | RAD52 | P43351 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.98 |
| ▸ | TSHR | P16473 | 5/20 | 0.98 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | MAOA | P21397 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HTR3A | P46098 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benoxinate SCHEMBL1649661 | 1.00 | RAD52 (1.00) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| Benoxinate SCHEMBL25087 | 0.99 | CYP2D6 (1.00) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| Benoxinate SCHEMBL30849863 | 0.99 | CYP2D6 (1.00) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| Benoxinate SCHEMBL15532182 | 0.96 | CYP2D6 (0.95) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| Benoxinate SCHEMBL16633604 | 0.94 | CYP2D6 (0.91) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| Benoxinate SCHEMBL18740891 | 0.93 | CYP2D6 (0.89) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| SCHEMBL13439964 | 0.93 | CYP2D6 (0.89) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| Betoxycaine SCHEMBL6898673 | 0.90 | CYP2D6 (0.82) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| SCHEMBL10533525 | 0.89 | CYP2D6 (0.83) | RAD52CYP2D6CYP1A2SCN1ASCN2A | |
| SCHEMBL14304165 | 0.89 | CYP2D6 (0.82) | RAD52CYP2D6CYP1A2SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2289 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122005204-A | Frameless amniotic mirror device, manufacturing method and using method | 济南市第二人民医院(济南市眼科医院、济南市眼视光医院) | 2026-05-12 | — | — | CN | claimed |
| CN-119735519-A | Method for improving clarity and color of solution in oxybuprocaine hydrochloride | 辰欣药业股份有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119678884-A | Method for constructing atrophic meibomian gland dysfunction animal model and animal model | 哈尔滨医科大学 | 2025-03-25 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-11998603-B2 | Fluorescein and benoxinate compositions | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT | 2024-06-04 | — | — | US | claimed |
| WO-2024102612-A1 | COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS FOR MODULATING GLUCOSE TRANSPORT | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-16 | — | — | WO | claimed |
| CN-117731859-A | Medical catheter | 湖北医药学院 | 2024-03-22 | — | — | CN | claimed |
| CN-117243179-A | Method for preparing mouse CNV model and bearing device | 上海朗昇生物科技有限公司 | 2023-12-19 | — | — | CN | claimed |
| CN-117132983-A | Method for automatically identifying lens module of electronic endoscope | 武汉半边天医疗技术发展有限公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117084850-A | Ultrasonic emulsification and folding artificial lens implantation method for cataract | 中国人民解放军总医院第三医学中心 | 2023-11-21 | — | — | CN | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5858996-A | ACRYLIC POLYMER, AMINO TRI(LOWER ALKYLENE PHOSPHONIC ACID) CHELATING AGENT; OPHTHALMIC DELIVERY | CIBA VISION CORPORATION (US) | 1999-01-12 | — | — | US | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0844868-A1 | COMPOSITIONS INCLUDING O-CARBOXYALKYL CHITOSAN AND METHODS OF USE IN OPHTHALMICS | Novartis AG (CH) | 1998-06-03 | — | — | EP | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0833609-A1 | COMPOSITIONS AND METHODS FOR STABILIZING POLYMERS | Novartis AG (CH) | 1998-04-08 | — | — | EP | claimed |
| US-5624962-A | FOR OPHTHALMIC, DERMATOLOGICAL AND BADY CAVITICAL USE | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | claimed |
| WO-1997006782-A1 | COMPOSITIONS INCLUDING O-CARBOXYALKYL CHITOSAN AND METHODS OF USE IN OPHTHALMICS | NOVARTIS AG (CH) | 1997-02-27 | — | — | WO | claimed |
| WO-1997000669-A1 | COMPOSITIONS AND METHODS FOR STABILIZING POLYMERS | NOVARTIS AG (CH) | 1997-01-09 | — | — | WO | claimed |
| EP-0694310-A1 | REVERSIBLE, THERMALLY GELLING WATER-BASE MEDICINAL COMPOSITION | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1996-01-31 | — | — | EP | claimed |